
袁艳,教授,博士生导师
科学研究方向:
1. 多能干细胞与精子分化
2. 睾丸类器官与男性生育力维持
3. 类胚胎构建
邮箱:yuanyan@njmu.edu.cn
个人简介:
国家优秀青年基金获得者,科技部重点研发项目青年首席,江苏省青年医学人才。长期致力于胚胎干细胞(ESC)和诱导多能干细胞(iPSC)分化、睾丸类器官重构、精子发生及相关机制研究,以通讯作者/第一作者在Cell Stem Cell、Cell Research、Cell Proliferation等国际刊物上发表多篇SCI论文。授权7项发明专利。多次参加国际会议并作会议报告;获Lalor Foundation Merit Awards Winner;Best International Abstract。
承担科研课题:(省部级以上)
1. 国家科学技术部,国家重点研发计划,精子发生障碍的生育力重塑研究,2022YFC2702800,2022-12至2025-11,300万,在研,主持
近五年代表性论文:
1. Mengjie Wang #, Laihua Li #, Qing Cheng #, Hao Zhang, Zhaode Liu, Yiqiang Cui *, Jiahao Sha *, Yan Yuan *. HumanTestisDB: A Comprehensive Atlas of Testicular Transcriptomics and Cellular Interactions. Genomics Proteomics Bioinformatics. 2025 May 10;23(1): qzaf015.
2. Yu Xia #, Xiaoxuan Zhang #, Bohang Zhang #, Minhui Lu #, Qing Cheng, Li Liu, Lifang Shi, Yiqiang Cui, Dingdong Chen, Laihua Li, Xuejiang Guo, Jingtao Guo, Jiahao Sha *, Yuanjin Zhao *, Yan Yuan *. A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche. Advanced Science. 2025 Jul 28: e02435.
3. Mingqian Huang #, Mengqi Chen #, Gege Yuan #, Yiqiang Cui #, Bin Shen, Zhaode Liu, Bohang Zhang, Junqing Chen, Dingdong Chen, Shuangshuang Qiu, Yichun Zhang, Li Liu, Lianju Qin, Yunfei Zhu, Jiayin Liu, Hao Zhang*, Jun Wu*, Yan Yuan*, Jiahao Sha*. Establishment of human gastrulating stem cells with the capacity of stable differentiation into multiple gastrulating cell types. Cell Research.2025 Aug 6, 1-16.
4. Zhu P#, Zhang B#, Sun R#, Wang J#, Liu Z, Liu X, Yan M, Cui Y*, Sha J*, Yuan Y*. Derivation of new pluripotent stem cells from human extended pluripotent stem cells with formative features and trophectoderm potential. Cell Prolif. 2023 Apr 13:e13480.
5. Yuan Y#, Li LH#, Cheng Q#, Diao FY#, Zeng Q#, Yang XY, Wu YB, Zhang H, Huang MQ, Chen JQ, Zhou Q, Zhu YF, Hua R, Tian JY, Wang X, Zhou ZM, Hao J, Yu JJ, Hua D, Liu JY, Guo XJ*, Zhou Q*, Sha JH*; In vitro testicular organogenesis from human fetal gonads produces fertilization-competent spermatids, Cell Research.2020, 30: 244-255.